Holladay Distillery sits on a quiet lane in Weston, Missouri, claiming the title of the oldest distillery west of the Mississippi River. Ben Holladay established the operation in 1856, and after surviving Prohibition, fires, and changing ownership over the decades, it’s now part of the McCormick Distilling Company family. The brick buildings house copper stills and aging warehouses where they produce bourbon, vodka, gin, and rum for both their own labels and private clients. The facility operates as both a working distillery and visitor destination, offering tours that walk you through 160+ years of Missouri distilling history. You’ll find it tucked away in historic Weston, a rivertown that once served as a major jumping-off point for westward expansion. The distillery has weathered everything from Civil War raids to corporate buyouts, but it’s still making spirits on the same spot where Holladay first fired up his stills before the Civil War.